Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast‐flow vascular anomalies are caused by RASA1 mutations
Identifieur interne : 000218 ( France/Analysis ); précédent : 000217; suivant : 000219Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast‐flow vascular anomalies are caused by RASA1 mutations
Auteurs : Nicole Revencu [Belgique] ; Laurence M. Boon [Belgique] ; John B. Mulliken [États-Unis] ; Odile Enjolras [France] ; Maria Rosa Cordisco [Argentine] ; Patricia E. Burrows [États-Unis] ; Philippe Clapuyt [Belgique] ; Frank Hammer [Belgique] ; Josée Dubois [Canada] ; Eulalia Baselga [Espagne] ; Francesco Brancati [Italie] ; Robin Carder [États-Unis] ; José Miguel Ceballos Quintal [Mexique] ; Bruno Dallapiccola [Italie] ; Gayle Fischer [Australie] ; Ilona J. Frieden [États-Unis] ; Maria Garzon [États-Unis] ; John Harper [Royaume-Uni] ; Jennifer Johnson-Patel [États-Unis] ; Christine Labrèze [France] ; Loreto Martorell [Espagne] ; Harriet J. Paltiel [États-Unis] ; Annette Pohl [Allemagne] ; Julie Prendiville [Canada] ; Isabelle Quere [France] ; Dawn H. Siegel [États-Unis] ; Enza Maria Valente [Italie] ; Annet Van Hagen [Pays-Bas] ; Liselot Van Hest [Pays-Bas] ; Keith K. Vaux [États-Unis] ; Asuncion Vicente [Espagne] ; Lisa Weibel [Royaume-Uni] ; David Chitayat [Canada] ; Miikka Vikkula [Belgique]Source :
- Human Mutation [ 1059-7794 ] ; 2008-07.
English descriptors
- KwdEn :
Abstract
Capillary malformation‐arteriovenous malformation (CM‐AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1 mutations and the associated phenotype in 44 families. The penetrance and de novo occurrence were high. All affected individuals presented multifocal capillary malformations (CMs), which represent the hallmark of the disorder. Importantly, one‐third had fast‐flow vascular lesions. Among them, we observed severe intracranial AVMs, including vein of Galen aneurysmal malformation, which were symptomatic at birth or during infancy, extracranial AVM of the face and extremities, and Parkes Weber syndrome (PKWS), previously considered sporadic and nongenetic. These fast‐flow lesions can be differed from the other two genetic AVMs seen in hereditary hemorrhagic telangiectasia (HHT) and in phosphatase and tensin homolog (PTEN) hamartomatous tumor syndrome. Finally, some CM‐AVM patients had neural tumors reminiscent of neurofibromatosis type 1 or 2. This is the first extensive study on the phenotypes associated with RASA1 mutations, and unravels their wide heterogeneity. Hum Mutat 29(7), 959–965, 2008. © 2008 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/humu.20746
Affiliations:
- Allemagne, Argentine, Australie, Belgique, Canada, Espagne, France, Italie, Mexique, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Aquitaine, Bade-Wurtemberg, Californie, Catalogne, District de Fribourg-en-Brisgau, Grand Londres, Hollande-Septentrionale, Languedoc-Roussillon, Latium, Massachusetts, Nouvelle-Aquitaine, Occitanie (région administrative), Province du Brabant wallon, Québec, Région de Bruxelles-Capitale, Région wallonne, Texas, État de New York, Île-de-France
- Amsterdam, Barcelone, Bordeaux, Bruxelles, Fribourg-en-Brisgau, Londres, Louvain-la-Neuve, Montpellier, Montréal, Paris, Rome
- Université catholique de Louvain
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ISTEX:4150C8B56E743638F6F1342D58F1D8DFDA22D68DLe document en format XML
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Mulliken</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Vascular Anomalies Center, Division of Plastic Surgery and Department of Radiology, Children's Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Enjolras, Odile" sort="Enjolras, Odile" uniqKey="Enjolras O" first="Odile" last="Enjolras">Odile Enjolras</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre Multidisciplinaire des Angiomes de l'enfant, AP‐HP, Hôpital d'enfants Armand‐Trousseau, Service de Chirurgie Maxillo‐Faciale et Chirurgie Plastique, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cordisco, Maria Rosa" sort="Cordisco, Maria Rosa" uniqKey="Cordisco M" first="Maria Rosa" last="Cordisco">Maria Rosa Cordisco</name><affiliation wicri:level="1"><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Pediatric Dermatology, Hospital de Pediatria Dr. J.P. Garrahan, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Burrows, Patricia E" sort="Burrows, Patricia E" uniqKey="Burrows P" first="Patricia E." last="Burrows">Patricia E. Burrows</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Vascular Anomalies Center, Division of Plastic Surgery and Department of Radiology, Children's Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Clapuyt, Philippe" sort="Clapuyt, Philippe" uniqKey="Clapuyt P" first="Philippe" last="Clapuyt">Philippe Clapuyt</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiology, Cliniques universitaires Saint‐Luc, Université catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Louvain-la-Neuve</settlement></placeName><orgName type="university">Université catholique de Louvain</orgName></affiliation></author><author><name sortKey="Hammer, Frank" sort="Hammer, Frank" uniqKey="Hammer F" first="Frank" last="Hammer">Frank Hammer</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiology, Cliniques universitaires Saint‐Luc, Université catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Louvain-la-Neuve</settlement></placeName><orgName type="university">Université catholique de Louvain</orgName></affiliation></author><author><name sortKey="Dubois, Josee" sort="Dubois, Josee" uniqKey="Dubois J" first="Josée" last="Dubois">Josée Dubois</name><affiliation wicri:level="3"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Imaging, Sainte‐Justine Mother‐Child University Hospital, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Baselga, Eulalia" sort="Baselga, Eulalia" uniqKey="Baselga E" first="Eulalia" last="Baselga">Eulalia Baselga</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital de la Santa Creu I Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Brancati, Francesco" sort="Brancati, Francesco" uniqKey="Brancati F" first="Francesco" last="Brancati">Francesco Brancati</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS CSS, Mendel Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Carder, Robin" sort="Carder, Robin" uniqKey="Carder R" first="Robin" last="Carder">Robin Carder</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Quintal, Jose Miguel Ceballos" sort="Quintal, Jose Miguel Ceballos" uniqKey="Quintal J" first="José Miguel Ceballos" last="Quintal">José Miguel Ceballos Quintal</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Genética, Universidad Autónoma de Yucatán Mérida, Yucatán</wicri:regionArea><wicri:noRegion>Yucatán</wicri:noRegion></affiliation></author><author><name sortKey="Dallapiccola, Bruno" sort="Dallapiccola, Bruno" uniqKey="Dallapiccola B" first="Bruno" last="Dallapiccola">Bruno Dallapiccola</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS CSS, Mendel Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fischer, Gayle" sort="Fischer, Gayle" uniqKey="Fischer G" first="Gayle" last="Fischer">Gayle Fischer</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Royal North Shore Hospital, St Leonards</wicri:regionArea><wicri:noRegion>St Leonards</wicri:noRegion></affiliation></author><author><name sortKey="Frieden, Ilona J" sort="Frieden, Ilona J" uniqKey="Frieden I" first="Ilona J." last="Frieden">Ilona J. Frieden</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departement of Dermatology, School of Medicine, University of California, San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Garzon, Maria" sort="Garzon, Maria" uniqKey="Garzon M" first="Maria" last="Garzon">Maria Garzon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Dermatology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Harper, John" sort="Harper, John" uniqKey="Harper J" first="John" last="Harper">John Harper</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pediatric Dermatology, Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Johnson Atel, Jennifer" sort="Johnson Atel, Jennifer" uniqKey="Johnson Atel J" first="Jennifer" last="Johnson-Patel">Jennifer Johnson-Patel</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Robert E. Bush Naval Hospital, Twenty‐nine Palms</wicri:cityArea></affiliation></author><author><name sortKey="Labreze, Christine" sort="Labreze, Christine" uniqKey="Labreze C" first="Christine" last="Labrèze">Christine Labrèze</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Pellegrin Enfants, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Martorell, Loreto" sort="Martorell, Loreto" uniqKey="Martorell L" first="Loreto" last="Martorell">Loreto Martorell</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica Molecular, Hospital Sant Joan de Déu, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Paltiel, Harriet J" sort="Paltiel, Harriet J" uniqKey="Paltiel H" first="Harriet J." last="Paltiel">Harriet J. Paltiel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Vascular Anomalies Center, Division of Plastic Surgery and Department of Radiology, Children's Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Pohl, Annette" sort="Pohl, Annette" uniqKey="Pohl A" first="Annette" last="Pohl">Annette Pohl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zentrum fur Kinderheilkunde und Jugendmedizin, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Prendiville, Julie" sort="Prendiville, Julie" uniqKey="Prendiville J" first="Julie" last="Prendiville">Julie Prendiville</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Dermatology, Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Quere, Isabelle" sort="Quere, Isabelle" uniqKey="Quere I" first="Isabelle" last="Quere">Isabelle Quere</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Siegel, Dawn H" sort="Siegel, Dawn H" uniqKey="Siegel D" first="Dawn H." last="Siegel">Dawn H. Siegel</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departement of Dermatology, School of Medicine, University of California, San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS CSS, Mendel Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Van Hagen, Annet" sort="Van Hagen, Annet" uniqKey="Van Hagen A" first="Annet" last="Van Hagen">Annet Van Hagen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Hest, Liselot" sort="Van Hest, Liselot" uniqKey="Van Hest L" first="Liselot" last="Van Hest">Liselot Van Hest</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Vaux, Keith K" sort="Vaux, Keith K" uniqKey="Vaux K" first="Keith K." last="Vaux">Keith K. Vaux</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pediatrics, Division of Dysmorphology and Teratology, University of California, San Diego, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Vicente, Asuncion" sort="Vicente, Asuncion" uniqKey="Vicente A" first="Asuncion" last="Vicente">Asuncion Vicente</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Dermatology, Hospital Sant Joan de Déu, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Weibel, Lisa" sort="Weibel, Lisa" uniqKey="Weibel L" first="Lisa" last="Weibel">Lisa Weibel</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pediatric Dermatology, Great Ormond Street Hospital for Children, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chitayat, David" sort="Chitayat, David" uniqKey="Chitayat D" first="David" last="Chitayat">David Chitayat</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>The Prenatal Diagnosis and Medical Genetics Program, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Vikkula, Miikka" sort="Vikkula, Miikka" uniqKey="Vikkula M" first="Miikka" last="Vikkula">Miikka Vikkula</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Louvain-la-Neuve</settlement></placeName><orgName type="university">Université catholique de Louvain</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Human Molecular Genetics (GEHU), de Duve Institute, Université catholique de Louvain, Avenue Hippocrate 74(+5), bp. 75.39, B‐1200 Brussels</wicri:regionArea><orgName type="university">Université catholique de Louvain</orgName><placeName><settlement type="city">Louvain-la-Neuve</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province du Brabant wallon</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Mutation</title><title level="j" type="abbrev">Hum. Mutat.</title><idno type="ISSN">1059-7794</idno><idno type="eISSN">1098-1004</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07">2008-07</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="959">959</biblScope><biblScope unit="page" to="965">965</biblScope></imprint><idno type="ISSN">1059-7794</idno></series><idno type="istex">4150C8B56E743638F6F1342D58F1D8DFDA22D68D</idno><idno type="DOI">10.1002/humu.20746</idno><idno type="ArticleID">HUMU20746</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1059-7794</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>NF1</term><term>NF2</term><term>Parkes Weber syndrome</term><term>RAS p21</term><term>RASA1</term><term>arteriovenous</term><term>arteriovenous fistula</term><term>capillary</term><term>hereditary benign telangiectasia</term><term>hereditary hemorrhagic telangiectasia</term><term>malformation</term><term>p120RasGAP</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Capillary malformation‐arteriovenous malformation (CM‐AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1 mutations and the associated phenotype in 44 families. The penetrance and de novo occurrence were high. All affected individuals presented multifocal capillary malformations (CMs), which represent the hallmark of the disorder. Importantly, one‐third had fast‐flow vascular lesions. Among them, we observed severe intracranial AVMs, including vein of Galen aneurysmal malformation, which were symptomatic at birth or during infancy, extracranial AVM of the face and extremities, and Parkes Weber syndrome (PKWS), previously considered sporadic and nongenetic. These fast‐flow lesions can be differed from the other two genetic AVMs seen in hereditary hemorrhagic telangiectasia (HHT) and in phosphatase and tensin homolog (PTEN) hamartomatous tumor syndrome. Finally, some CM‐AVM patients had neural tumors reminiscent of neurofibromatosis type 1 or 2. This is the first extensive study on the phenotypes associated with RASA1 mutations, and unravels their wide heterogeneity. Hum Mutat 29(7), 959–965, 2008. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Mexique</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Catalogne</li><li>District de Fribourg-en-Brisgau</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Languedoc-Roussillon</li><li>Latium</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Province du Brabant wallon</li><li>Québec</li><li>Région de Bruxelles-Capitale</li><li>Région wallonne</li><li>Texas</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Bordeaux</li><li>Bruxelles</li><li>Fribourg-en-Brisgau</li><li>Londres</li><li>Louvain-la-Neuve</li><li>Montpellier</li><li>Montréal</li><li>Paris</li><li>Rome</li></settlement><orgName><li>Université catholique de Louvain</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Revencu, Nicole" sort="Revencu, Nicole" uniqKey="Revencu N" first="Nicole" last="Revencu">Nicole Revencu</name></region><name sortKey="Boon, Laurence M" sort="Boon, Laurence M" uniqKey="Boon L" first="Laurence M." last="Boon">Laurence M. Boon</name><name sortKey="Boon, Laurence M" sort="Boon, Laurence M" uniqKey="Boon L" first="Laurence M." last="Boon">Laurence M. Boon</name><name sortKey="Clapuyt, Philippe" sort="Clapuyt, Philippe" uniqKey="Clapuyt P" first="Philippe" last="Clapuyt">Philippe Clapuyt</name><name sortKey="Hammer, Frank" sort="Hammer, Frank" uniqKey="Hammer F" first="Frank" last="Hammer">Frank Hammer</name><name sortKey="Revencu, Nicole" sort="Revencu, Nicole" uniqKey="Revencu N" first="Nicole" last="Revencu">Nicole Revencu</name><name sortKey="Vikkula, Miikka" sort="Vikkula, Miikka" uniqKey="Vikkula M" first="Miikka" last="Vikkula">Miikka Vikkula</name><name sortKey="Vikkula, Miikka" sort="Vikkula, Miikka" uniqKey="Vikkula M" first="Miikka" last="Vikkula">Miikka Vikkula</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mulliken, John B" sort="Mulliken, John B" uniqKey="Mulliken J" first="John B." last="Mulliken">John B. Mulliken</name></region><name sortKey="Burrows, Patricia E" sort="Burrows, Patricia E" uniqKey="Burrows P" first="Patricia E." last="Burrows">Patricia E. Burrows</name><name sortKey="Carder, Robin" sort="Carder, Robin" uniqKey="Carder R" first="Robin" last="Carder">Robin Carder</name><name sortKey="Frieden, Ilona J" sort="Frieden, Ilona J" uniqKey="Frieden I" first="Ilona J." last="Frieden">Ilona J. Frieden</name><name sortKey="Garzon, Maria" sort="Garzon, Maria" uniqKey="Garzon M" first="Maria" last="Garzon">Maria Garzon</name><name sortKey="Johnson Atel, Jennifer" sort="Johnson Atel, Jennifer" uniqKey="Johnson Atel J" first="Jennifer" last="Johnson-Patel">Jennifer Johnson-Patel</name><name sortKey="Paltiel, Harriet J" sort="Paltiel, Harriet J" uniqKey="Paltiel H" first="Harriet J." last="Paltiel">Harriet J. Paltiel</name><name sortKey="Siegel, Dawn H" sort="Siegel, Dawn H" uniqKey="Siegel D" first="Dawn H." last="Siegel">Dawn H. Siegel</name><name sortKey="Vaux, Keith K" sort="Vaux, Keith K" uniqKey="Vaux K" first="Keith K." last="Vaux">Keith K. Vaux</name></country><country name="France"><region name="Île-de-France"><name sortKey="Enjolras, Odile" sort="Enjolras, Odile" uniqKey="Enjolras O" first="Odile" last="Enjolras">Odile Enjolras</name></region><name sortKey="Labreze, Christine" sort="Labreze, Christine" uniqKey="Labreze C" first="Christine" last="Labrèze">Christine Labrèze</name><name sortKey="Quere, Isabelle" sort="Quere, Isabelle" uniqKey="Quere I" first="Isabelle" last="Quere">Isabelle Quere</name></country><country name="Argentine"><noRegion><name sortKey="Cordisco, Maria Rosa" sort="Cordisco, Maria Rosa" uniqKey="Cordisco M" first="Maria Rosa" last="Cordisco">Maria Rosa Cordisco</name></noRegion></country><country name="Canada"><region name="Québec"><name sortKey="Dubois, Josee" sort="Dubois, Josee" uniqKey="Dubois J" first="Josée" last="Dubois">Josée Dubois</name></region><name sortKey="Chitayat, David" sort="Chitayat, David" uniqKey="Chitayat D" first="David" last="Chitayat">David Chitayat</name><name sortKey="Prendiville, Julie" sort="Prendiville, Julie" uniqKey="Prendiville J" first="Julie" last="Prendiville">Julie Prendiville</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Baselga, Eulalia" sort="Baselga, Eulalia" uniqKey="Baselga E" first="Eulalia" last="Baselga">Eulalia Baselga</name></region><name sortKey="Martorell, Loreto" sort="Martorell, Loreto" uniqKey="Martorell L" first="Loreto" last="Martorell">Loreto Martorell</name><name sortKey="Vicente, Asuncion" sort="Vicente, Asuncion" uniqKey="Vicente A" first="Asuncion" last="Vicente">Asuncion Vicente</name></country><country name="Italie"><region name="Latium"><name sortKey="Brancati, Francesco" sort="Brancati, Francesco" uniqKey="Brancati F" first="Francesco" last="Brancati">Francesco Brancati</name></region><name sortKey="Dallapiccola, Bruno" sort="Dallapiccola, Bruno" uniqKey="Dallapiccola B" first="Bruno" last="Dallapiccola">Bruno Dallapiccola</name><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name></country><country name="Mexique"><noRegion><name sortKey="Quintal, Jose Miguel Ceballos" sort="Quintal, Jose Miguel Ceballos" uniqKey="Quintal J" first="José Miguel Ceballos" last="Quintal">José Miguel Ceballos Quintal</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Fischer, Gayle" sort="Fischer, Gayle" uniqKey="Fischer G" first="Gayle" last="Fischer">Gayle Fischer</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Harper, John" sort="Harper, John" uniqKey="Harper J" first="John" last="Harper">John Harper</name></region><name sortKey="Weibel, Lisa" sort="Weibel, Lisa" uniqKey="Weibel L" first="Lisa" last="Weibel">Lisa Weibel</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Pohl, Annette" sort="Pohl, Annette" uniqKey="Pohl A" first="Annette" last="Pohl">Annette Pohl</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Hagen, Annet" sort="Van Hagen, Annet" uniqKey="Van Hagen A" first="Annet" last="Van Hagen">Annet Van Hagen</name></region><name sortKey="Van Hest, Liselot" sort="Van Hest, Liselot" uniqKey="Van Hest L" first="Liselot" last="Van Hest">Liselot Van Hest</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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